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远程中心模型眼睛用于调整自适应光学眼镜镜中的图像扭曲

Vyas Akondi¹, Gastón A Ayubi², Xiaojing Huang²

¹Dept. of Physical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.

Biomedical optics express

|July 18, 2025

概括

这项研究引入了一个远程中心型眼睛模型,以提高自适应光学 (AO) 眼镜学生物标志物的可复制性. 模型眼睛精确地测量光学扭曲,提高了视网膜成像中的诊断准确性.

科学领域:

眼科医生眼科眼科
光学工程是指光学工程.
生物医学成像技术生物医学成像技术

背景情况:

适应光学 (AO) 眼镜镜对于高分辨率的视网膜成像至关重要.
AO眼镜学生物标志物的可复制性受到光学扭曲和扫描变异性的限制.
精确测量光学扭曲对于可靠的生物标志物量化至关重要.

研究的目的:

开发和验证一个远程中心型眼睛模型,用于测量AO眼镜中的扫描,采样和光学扭曲.
为了提高AO眼镜显微镜生物标志物的可复制性,在10二光子的焦点范围内.
评估模型视网膜特性和扫描方法对异常的影响.

主要方法:

一个带有衍射有限透镜的远心模型眼睛被设计用于800nm成像.
可变光圈停止控制的视野 (2.09.2°) 和瞳孔大小 (28毫米).
双通波面偏差被测量使用珀玻璃和粗的模型视网膜与扫描信标波面传感.

主要成果:

模型眼睛在指定的视野和光圈大小中展示了衍射有限的性能.
奥帕尔玻璃,粗的表面和扫描减轻了对AO眼镜学至关重要的第一通异常.
定制算法实现了0.06%的缩放和0.02°的剪切重复性,具有0.5%的可重复性.
根-平方平均剩余扭曲在整个场域和焦点范围的0.1像素被测量.

结论:

开发的远程中心模型眼睛可以精确测量AO眼镜中的光学扭曲.
该工具通过计算扫描和采样变化,提高了眼镜学生物标志物的可复制性.
这些发现有助于在视网膜成像研究和临床应用中进行更可靠的定量分析.

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