关于线粒体功能障碍和骨质疏松症之间的关系的研究进展:2014年至2024年的图书统计研究
Yun-Song Zhang1, Jia-Nan Yu2, Ming-Ze Han2
1School of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Frontiers in medicine
|July 18, 2025
概括
线粒体功能障碍导致骨质疏松症. 研究趋势显示,对氧化应激,线粒和 Ferroptosis 抑制剂等新疗法的研究增加,为骨健康提供了新的希望.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 老年学是一门学科.
背景情况:
- 骨质疏松症在老年人群中越来越令人担忧,其特点是骨密度低和骨折风险高.
- 线粒体功能障碍越来越被认为是骨质疏松症发展的关键因素.
- 需要对与骨质疏松症中线粒体相关的研究趋势和治疗途径进行全面分析.
研究的目的:
- 分析图书统计数据并确定研究趋势,协作模式和骨质疏松症研究中的新兴热点,重点关注线粒体.
- 绘制研究主题和跨学科联系的演变图.
- 突出潜在的治疗策略和未来的研究方向.
主要方法:
- 从科学网络核心集合中对780篇文章 (2014-2024) 的图书统计分析.
- 使用CiteSpace和VOSviewer进行数据可视化和分析.
- 确定了出版趋势,主要贡献者,关键期刊,核心主题和新兴的边界.
主要成果:
- 观察到骨质疏松症研究出版物的显著上升趋势.
- 中国和美国是主要的贡献者,诸如生物化学杂志和自然杂志等主要期刊发表了重要的研究成果.
- 核心研究主题包括氧化应激,细胞亡,线粒体亡和线粒体转移,铁亡和SIRT1信号通路成为新的前沿.
结论:
- 线粒体质量控制,氧化还原平衡和骨代谢相互关联,为骨质疏松症提供了分子洞察力.
- 针对氧化应激的治疗策略,如SIRT1激活剂和纳米粒子干预,显示出临床前的前景.
- 涉及线粒体转移和铁灭抑制剂的新方法为骨质疏松症治疗和骨缺陷修复提供了新的途径.
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