在常规临床护理中,自身免疫相关的外源性精神病的发生频率
Maria Buthut1,2,3, David Haslacher1, Surjo R Soekadar1
1Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, Charité Campus Mitte, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Brain, behavior, & immunity - health
|July 18, 2025
概括
自身免疫性精神病 (AIP) 是急性精神病发作的一个未被确诊的原因. 通过脑脊液分析和免疫疗法进行早期检测可以改善结果,强调需要进一步的诊断研究.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神病与各种疾病有关,但自身免疫过程往往被诊断不足.
- 临床症状可能表明自身免疫性脑炎 (AIE) 或自身免疫性精神病 (AIP).
- 这项研究的重点是确定患有急性发作患者精神病的自身免疫原因.
研究的目的:
- 评估急性精神病发作患者自身免疫精神病的警告标志和生物标志物.
- 评估社区心理病患者样本中自身免疫病因的患病率.
主要方法:
- 分析常规临床数据,包括血液,尿液,脑脊液,EEG和MRI.
- 使用商业查 (CAS) 和免疫光 (IFT) 检测抗神经元自身抗体的脑脊髓液 (CSF) 分析.
- 精神病的起源由ICD-10的出院诊断确定.
主要成果:
- 352名参与者被纳入了39个月的时间;114人有他们的第一次精神病发作 (FEP).
- CSF分析发现了四个潜在的AIP病例,只有一个通过CAS确认.
- 间接免疫光 (IFT) 检测了四名FEP患者的IgG自身抗体;三名患者通过免疫疗法得到改善.
结论:
- 在社区样本中存在自身免疫精神病 (AIP),尽管患病率可能很低.
- 商业测定检测到AIP病例比IFT少,这表明目前查的局限性.
- 有效免疫治疗的潜力强调了对精神病自身免疫原因进行全面诊断评估的需要.
相关概念视频
01:29Autoimmune Disorders
678
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
678
01:28Psychosis and Antipsychotic Drugs: Overview
459
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
459
01:29Psychological and Sociocultural Causes of Schizophrenia
190
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
190
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
987
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
987
01:26Psychosis: Goals of Pharmacotherapy
210
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
210
01:27Diagnostic and Statistical Manual of Mental Disorders (DSM)
155
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
155