癌症治疗后口腔微生物组的改变:一个范围的审查和分析
Francis A Boksa1, Leah I Leinbach1, Drashty P Mody1
1National Institute of Dental and Craniofacial Research, National Institutes of Health.
Research square
|July 18, 2025
概括
化疗和辐射等癌症疗法显著改变了口腔微生物群,增加了有害细菌. 了解这些变化对于改善癌症幸存者的口腔健康至关重要.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 口腔健康 口腔健康
背景情况:
- 众所周知,癌症疗法,包括放射,化疗和细胞疗法,都会影响口腔.
- 在癌症治疗后,口腔微生物转移的确切性质,持续时间和长期影响尚不清楚.
- 现有研究表明,这些疗法可以导致口腔失生症和致病微生物的增加.
研究的目的:
- 对正在接受癌症治疗的患者口腔微生物组的研究进行范围审查.
- 综合现有的关于癌症治疗相关的口腔微生物组变化的文献.
- 确定有关口腔微生物组对特定癌症治疗的反应及其对幸存者的长期健康影响的研究缺口.
主要方法:
- 对已发表的文献进行了全面的范围审查.
- 专注于接受癌症治疗的患者口腔微生物组的研究被系统地确定和分析.
- 结果被分类,以提供当前研究格局的广泛概述.
主要成果:
- 62项研究显示,由于化疗,放射治疗和干细胞移植,口腔微生物群落发生了显著的变化.
- 癌症治疗往往增加了微生物丰富性,但降低了物种均性,表明少数物种的主导地位.
- 常见的转变包括有益细菌的减少 (例如,链球菌,Prevotella) 和机会性病原体的增加 (例如,Candida albicans,金黄色葡萄球菌).
结论:
- 这一审查为未来对癌症幸存者的口腔微环境和健康要求的研究奠定了基础.
- 与特定的癌症治疗方式相关的微生物组合的鉴定改变提高了我们对其影响的理解.
- 需要进一步的研究,以充分阐明癌症幸存者的长期口腔健康后果.
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