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Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

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肺癌静脉注射在芯片上:可视化和机器学习辅助的自动量化.

Christy Wing Tung Wong^1,2,3, Joyce Zhi Xuen Lee^1,2, Anna Jaeschke^1,2,3

¹Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Bioactive materials

|July 18, 2025

概括

研究人员使用微流体学和机器学习开发了一种先进的肺癌转移模型,以研究瘤细胞输血. 这种创新的芯片技术加速了药物发现,并个性化了癌症治疗.

关键词:

癌症的血管内扩散.皮质到介质细胞的转变 (EMT)图像细分图像细分图像细分肺癌是一种肺癌.机器学习辅助的图像处理巨细胞是一个巨细胞.微流体设备的使用方法模式识别模式识别模式识别随机的森林随机的森林转化生长因子β1 (TGF-β1) 的转化生长因子-β1 (TGF-β1) 的转化生长因子-β1 (TGF-β1) 的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化生长因子-β1的转化.

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科学领域:

在瘤学瘤学.
生物技术是生物技术.
细胞生物学细胞生物学

背景情况:

肺癌转移涉及表皮细胞到介质细胞的过渡 (EMT),使瘤细胞能够入侵血管.
了解静脉注射对于开发有效的抗转移疗法至关重要.

研究的目的:

开发一种人体体外微生理学模型,用于研究EMT驱动的肺癌静脉注射.
利用机器学习来自动识别和量化血管内事件.

主要方法:

使用巨受条件介质和TGF-β1.1制备一种诱导EMT的尾酒 (EMT-IC).
在暴露于EMT-IC的微流体器件中与微血管网络 (MVN) 共同培养肺瘤微量质.
采用机器学习辅助的船舶细分和同定位分析来检测输入.

主要成果:

在24小时内,EMT-IC促进了瘤细胞膜突起和输血进入MVN.
EMT-IC降低了底层膜和血管接口蛋白 (胺素,VE-Cadherin),增加了血管的透性.
该模型显示了细胞特异性敏感性,反映了不同肺癌细胞系的转移潜力.

结论:

开发的"芯片上输血"模型为研究癌症转移提供了一个生理学上相关的平台.
这种高分辨率的快速模型有望加速药物开发,并为个性化癌症治疗策略提供信息.