全球变暖可能会导致人类呼吸道脱水和炎症
David A Edwards1,2,3, Aurélie Edwards4, Dan Li5
1Center for Nanomedicine, Johns Hopkins University Medical School, Baltimore, United States.
概括
呼吸干燥的空气会稀释气道的粘液,并引起气道的炎症,可能会恶化肺部疾病. 到2050年,气候变化可能会增加美国许多人的风险.
科学领域:
- 环境科学 环境科学
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
背景情况:
- 全球变暖正在增加地球生态系统的蒸发速度.
- 脱水的大气可以影响人类的呼吸系统健康.
- 呼吸道炎症与各种肺部疾病有关.
研究的目的:
- 研究呼吸干燥空气对气道粘液和炎症的影响.
- 预测未来气候变化导致的气道炎症风险.
主要方法:
- 在气道中的水蒸发的数学建模.
- 在体外实验中,人类气管-支气管细胞暴露于不同湿度水平.
- 在体内实验中,小鼠表现出粘膜炎症表型.
- 气候模型模拟用于预测未来的环境条件.
主要成果:
- 干燥的空气逐渐稀释了气道的粘液层和压缩的上皮细胞.
- 表皮细胞的压缩导致炎症性细胞因子 (TNF-α,IL-33,IL-6) 的分泌量增加.
- 暴露在干燥空气中的小鼠显示了他的病理学变化和改变的炎症透.
- 气候模型预测,在美国,暴露于脱水大气的风险增加.
结论:
- 呼吸干燥空气的蒸发会促进呼吸道炎症,并可能加剧肺部疾病.
- 由于气候变化导致大气干燥程度的增加,造成呼吸道炎症的风险越来越大.
- 到本世纪下半叶,美国大部分地区可能面临呼吸道炎症的高风险.
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