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长期的安卓素滥用后的低子体症:潜在的机制和拟议的标准化诊断
Joël van Os1, Diederik Laurens Smit2, Peter Bond2
1Spaarne Gasthuis, Department of Internal Medicine, Haarlem, Netherlands.
Frontiers in endocrinology
|July 18, 2025
概括
对雄激素的滥用会导致长期的阴性双胞胎症,这是一个缺乏明确定义的疾病. 我们提出"长期后素滥用性阴性腺症" (PPAAH),以标准化诊断并指导研究其机制.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 对雄激素的滥用越来越普遍,经常导致下丘脑-垂体-阴茎轴 (HPGA) 抑制.
- 虽然大多数人在停止HPGA功能后恢复,但有些人经历了持续数月到几年的持续性阴性腺功能衰竭.
- 缺乏标准化的定义,阻碍了对这种长期病情的诊断和治疗.
研究的目的:
- 为了探索在滥用雄激素后延长性阴性恋的潜在机制.
- 建议对这种情况提出一个标准化的定义和术语:长期的安卓素滥用后阴性腺症 (PPAAH).
主要方法:
- 审查潜在的病理生理机制,包括荷尔蒙,遗传和行为因素.
- 基于低阴性和雄激素暴露的持续时间的PPAAH临时定义的建议.
- 重点是排除其他原因的催眠症的诊断.
主要成果:
- 确定了导致长期性阴性恋的关键因素:持续的雄激素活性,下丘脑-垂体功能障碍,丸变化,抑制的SHBG,遗传因素和持续的滥用.
- 拟议的PPAAH定义:在停止使用雄激素后6个月的持续性阴性,累计暴露≥150毫克/周≥6个月.
- 强调了对差异诊断的必要性,以排除其他催眠症的原因.
结论:
- PPAAH是一个拟议的术语,用于标准化在滥用雄激素后持续性阴性恋的诊断.
- 该框架旨在促进进一步研究PPAAH的病理生理学和有效的管理策略.
- 提出的PPAAH的定义和理解可能会随着新出现的科学证据而演变.
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