相关实验视频
Updated: Sep 15, 2025

09:29
Author Spotlight: Hypothalamic Neural Mechanism Insights
Published on: August 4, 2023
3.9K
侧面的囊有助于调节体温
Xuxin Wang1, Xiaowei Chen1,2, Zehui Zhang1
1Department of Physiology, College of Basic Medical Sciences, Jilin University, Xinmin Street No. 126, Changchun 130021, People's Republic of China.
iScience
|July 18, 2025
概括
在侧面的 habenula.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
背景情况:
- 侧面大脑 (LHb) 参与各种生理功能,包括温度调节.
- 它与调节体温的大脑区域的联系已知,但其直接作用尚不清楚.
研究的目的:
- 调查侧面大脑 (LHb) 谷氨酸神经元在体温调节中的直接作用.
- 在温度调节中探索连接侧向前视区域 (LPO) 和LHb的神经电路.
主要方法:
- 在小鼠中对LHb谷氨酸性神经元进行化学遗传和光遗传操纵.
- 使用光遗传学记录和激活LPO-LHb神经回路.
主要成果:
- 损害LHb谷氨酸性神经元导致小鼠患有不耐寒症.
- 确定了一个从热激活的LPO GABAergic神经元到冷激活的LHb glutamatergic神经元的神经电路.
- 激活LPO-LHb电路可以降低体温.
结论:
- 对于维持体温至关重要的是 LHb 谷氨酸性神经元.
- LPO-LHb神经回路在温度调节中起着重要作用.
相关概念视频
Body Temperature
2.9K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
2.9K
Thermoregulation
1.3K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.3K
Diencephalon: Anatomical Regions
2.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.9K
Diencephalon: Hypothalamus and Coordination
2.2K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
2.2K
Thermosensation
31.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.8K
Homeostatic Imbalances in Body Temperature
204
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
204

