食可发酵聚醇通过M1巨分化和肠道微生物群为肠道炎症提供燃料
Kensuke Sato1,2,3, Miwa Tomioka1, Masahiro Akiyama1
1Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
iScience
|July 18, 2025
概括
聚醇的消费,就像卜醇一样,会使小鼠的肠道炎症和结肠炎恶化. 通过肠道微生物群和代谢物的变化来激活肠道巨细胞,从而促进炎症反应.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 可发酵的橄糖,二糖,单糖和多醇 (FODMAP) 与炎症性肠病 (IBD) 症状恶化有关.
- 通过FODMAPs影响肠道微生物群和炎症的确切机制尚不清楚.
研究的目的:
- 为了研究一种常见的多聚醇 - - 索尔比托尔 - - 对小鼠中德克斯硫酸盐 (DSS) 诱导的大肠炎的影响.
- 阐明比醇在调节肠道微生物群,巨细胞两极分化和肠道炎症中的作用.
主要方法:
- 在小鼠中使用DSS和施用sorbitol诱导大肠炎.
- 在结肠中分析炎症基因表达 (例如,Il1b) 和巨分化 (M1).
- 评估肠道微生物群组成和代谢物概况.
- 使用IL-1β缺乏的小鼠和抗生素治疗来评估保护作用的实验.
主要成果:
- 比醇加剧了DSS诱导的大肠炎,增加了像Il1b.这样的炎症基因的结肠表达.
- 索尔比托治疗导致结肠中M1巨细胞的比例更高,使结肠炎恶化.
- 这些效应在IL-1β缺乏的小鼠中逆转,并通过抗生素治疗减轻.
- 索尔比托改变了肠道微生物群的组成和代谢物,与Prevotellaceae和胺与M1巨细胞有积极的相关性.
- 研究人员发现,用胺激活可以增强M1巨细胞的两极分化.
结论:
- 摄入多,特别是,通过肠道微生物组的改变激活肠道巨细胞.
- 这种激活促进肠道炎症并加剧结肠炎,突出显示IBD的潜在饮食触发因素.
- 准微生物组及其代谢物可能提供治疗策略,用于管理聚醇诱导的肠道炎症.
相关概念视频
Irritable Bowel Syndrome I: Introduction
392
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
392
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
424
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
424
Microbial Fermentation
399
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
399
What is Monogastric Digestion?
72.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.5K
Chronic Bowel Disorders: Introduction
541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541


