两个thalamostriatal系统在视觉触发的决策中的不同角色
Shigeki Kato1, Masateru Sugawara1, Miwako Yamasaki2
1Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
两种特定的thalamostriatal通道在马尔莫塞特有不同的角色在决策. 副状核-尾状核路径对于逆转学习的行为至关重要,而中心中间核-状核路径则有助于获得新的视觉任务.
科学领域:
- 神经科学是一个神经科学.
- 灵长类的认知能力
背景情况:
- 皮质 - 基底腺节电路对于运动控制,认知和情绪至关重要.
- 塔拉莫斯特里亚特途径与动物的行为学习,切换和从缺陷中恢复有关.
研究的目的:
- 在非人类灵长类动物中,研究两条thalamostriatal通路,即状细胞核 (Pf) - 尾状细胞核 (Cd) 和中枢细胞核 (CM) - 状细胞核 (Pu) 的不同作用.
- 了解他们在学习和决策过程中的参与.
主要方法:
- 选择性神经通路准在普通小熊猫.
- 在视觉区分和运动技能学习任务中的绩效评估.
主要成果:
- 针对Pf-Cd路径损害了反向学习,增加了持久性错误.
- 准CM-Pu路径干扰了视觉歧视任务的获取.
- 两种途径的向都没有影响运动技能学习.
结论:
- 在依赖感官提示的决策过程中,Pf-Cd 和 CM-Pu 状三角管道起着不同的作用.
- 这些途径在灵长类动物的学习和行为灵活性中具有差异性.
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