自我报告的治疗负担:维生素K和非维生素K口服抗凝剂之间的比较
Miroslav Mihajlovic1, Nevena Zec2, Jelena Simic1
1Cardiology Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
Exploratory research in clinical and social pharmacy
|July 18, 2025
概括
接受维生素K对抗剂 (VKA) 治疗的患者的治疗负担 (TBN) 比服用非维生素K口服抗凝剂 (NOAC) 的患者更高. 这主要是由于VKA的食物相互作用和INR监测需求.
科学领域:
- 药理学 药理学是指药理学的学科.
- 患者护理 患者护理
- 健康结果的健康结果.
背景情况:
- 治疗负担 (TBN) 显著影响患者的福祉和治疗坚持.
- 高TBN与不良事件有关;分数≥59被认为是不可接受的.
- 了解抗凝剂之间的TBN差异对于优化患者护理至关重要.
研究的目的:
- 为了比较服用维生素K对抗剂 (VKA) 和非维生素K口服抗凝剂 (NOAC) 的患者之间的TBN.
- 确定这些患者群体中不可接受的高TBN得分的流行率.
- 在使用VKA与NOAC的患者中识别导致TBN的因素.
主要方法:
- 从2019年4月到6月进行了一项横截面研究.
- 给心脏病患者使用的17个问题TBN问卷.
- 分析包括320名接受口服抗凝剂治疗 (OAC) 的患者,其中206名接受VKA.
主要成果:
- 与NOAC患者 (41.8 ± 19.7) 相比,VKA患者 (48.8 ± 26.5) 的平均TBN得分显著高于NOAC患者 (41.8 ± 19.7).
- 不能接受的高TBN (≥59) 在VKA患者 (30.1%) 与NOAC患者 (18.4%) 之间更频繁地报告.
- VKA患者报告了与INR监测和饮食限制相关的更高的TBN.
结论:
- 与NOAC相比,VKA治疗与显著更高的TBN和不可接受的高TBN的更大流行率有关.
- 维卡与食品的相互作用和频繁的INR监测是增加TBN的关键因素.
- 切换到NOAC可能会减少TBN,可能会改善患者的治疗结果.
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