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帕金森病中的步态动态和脑功能异常与步态结:使用静止状态fMRI和可穿戴设备的临床研究

Xiaohong Li¹, Mengdi Hou², Yan Qu³

¹Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Frontiers in neuroscience

|July 18, 2025

概括

帕金森病 (PD) 患者的步态结 (FoG) 显示大脑活动的广泛变化,特别是在皮质和小脑. 这与没有FoG的PD患者形成鲜明对比,他们表现出基底腺活动减少.

科学领域:

神经科学是一个神经科学.
神经学神经学
运动障碍运动障碍

背景情况:

在帕金森病 (PD) 中,步态结 (FoG) 显著损害了运动能力和生活质量.
与PD相关的FoG (PDFoG) 的潜在神经机制尚不清楚.
了解PDFoG病理生理学对于开发有针对性的干预措施至关重要.

研究的目的:

在PDFoG患者中调查和描述异常区域大脑活动.
为了比较PDFoG患者,PD无FoG患者 (PDnFoG) 和健康对照患者之间的神经活动模式.
为了识别与帕金森病中FoG相关的独特的神经特征.

主要方法:

在多个频段中使用的低频波动幅度 (ALFF),fALFF,PerAF和波幅-ALFF.
在PDFoG患者,PDnFoG患者和健康对照中评估区域大脑活动.
雇员临床评估 (FOG-Q,MDS-UPDRS III) 和基于可穿戴传感器的步态分析.

主要成果:

与PDnFoG患者和对照患者相比,PDFoG患者表现出更广泛的区域大脑活动变化.
在PDFoG中,大脑活动的改变主要观察到皮质区域和小脑.
PDnFoG患者主要表现出基底腺内的活性降低.

结论:

大脑皮层和小脑在PDFoG的病理生理学中起着重要的作用.
独特的神经活动模式将PDFoG与没有FoG的PD区分开来.
对皮层和小脑干涉的进一步研究是有必要的PDFoG.

关键词:

低频波动的幅度是低频波动的幅度.结了人的步态.步态动态步态动态帕金森氏症是帕金森氏病的一种疾病.静止状态的fMRI进行.

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