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用于抗生物膜应用的氧化和抗菌聚合物的光介导激活

Siyuan Luo¹, Zuotao Zhou¹, Yu Jin¹

¹School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, 230026, China. shenzq@ustc.edu.cn.

Journal of materials chemistry. B

|July 18, 2025

概括

这项研究引入了一种光激活的纳米粒子系统,该系统释放氧化 (NO) 并激活抗菌聚合物. 这种双重作用的方法有效地破坏了耐抗生素的细菌生物膜,为感染治疗提供了新的策略.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
传染性疾病传染性疾病

背景情况:

细菌生物膜在治疗持久性感染方面存在重大挑战,原因是它们的强大结构和抗生素耐药性.
目前的治疗方法往往难以穿透生物膜并有效地根除嵌入的细菌.

研究的目的:

开发一种对光敏感的纳米粒子系统 (PNO@Ir),用于协同输送氧化 (NO) 和抗菌聚合物激活.
调查由绿色光照射触发的级联激活机制,以增强生物膜破坏.
评估PNO@Ir系统在体外和体内对抗甲素耐药黄金葡萄球菌 (MRSA) 生物膜的疗效.

主要方法:

将一氧化 (NO) 捐赠聚合物 (PNO) 与光敏感剂 *fac*-Ir(ppy) 集成到纳米粒子系统中.
利用绿光照射触发NO释放和通过三重三重能量转移 (TTET) 和光诱导电子转移 (PeT) 激活抗菌聚合物.
在酸性和缺氧条件下研究纳米粒子重组,从而导致表面电荷逆转和增强细菌亲和力.
进行体外和体内研究,包括小鼠伤口感染模型,以评估生物膜破坏的有效性.

主要成果:

PNO@Ir系统证明了光触发的NO释放和抗菌聚合物的激活.
在特定条件下的纳米粒子重组导致增强的细菌亲和力.
观察到MRSA生物膜的显著破坏,无论是*in vitro*还是*in vivo*.
级联激活策略在对抗抗生素耐药性细菌感染方面被证明是有效的.

结论:

开发的PNO@Ir纳米粒子系统提供了一个协同作用的和空间时间可控的平台,用于对抗抗生素耐药的细菌感染.
这种方法在开发针对具有挑战性的生物膜相关感染的新型治疗策略方面具有重大潜力.
释放NO和激活抗菌聚合物的组合为未来的抗菌疗法提供了一个有希望的途径.

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