研究Yajieyixin配方改善动脉样硬化的机制
Shihua Luo1, Xiaoli Jiang2, Yi Li3
1Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Yunnan, China/The Affiliated Hospital of Yunnan University of Chinese Medicine.
Pakistan journal of pharmaceutical sciences
|July 18, 2025
概括
雅杰素配方 (YJYXF) 通过改善脂质水平和减少炎症,有效治疗小鼠的动脉样硬化 (AS). 它的机制包括调节肠道微生物群和胆酸代谢,为心血管疾病管理提供了一种新的方法.
科学领域:
- 传统中国医药 传统中国医药
- 心血管药理学心血管药理学
- 微生物组研究 微生物组研究
背景情况:
- 动脉样硬化 (AS) 是一个重大的全球健康挑战.
- 雅杰素配方 (YJYXF) 是一种用于心血管疾病的传统大药处方.
- 了解YJYXF在AS中的机制对于其治疗应用至关重要.
研究的目的:
- 在动脉样硬化小鼠模型中研究YJYXF的治疗效果和潜在机制.
- 分析YJYXF对脂质代谢,炎症和肠道微生物群的影响.
主要方法:
- 在ApoE小鼠中,高脂肪饮食引起的动脉样硬化模型.
- 用YJYXF的两个剂量 (36.075g/kg和12.025g/kg) 治疗12周.
- 综合分析包括生物化学和炎症标志物,斑块评估 (HE,油红O),肝脏代谢,微生物组概况,胆酸分析和基因/蛋白质表达 (FXR,FGF-15,CYP7A1).
主要成果:
- YJYXF显著降低了血脂水平和大动脉斑块的积累.
- 治疗调节了肝脂和胆酸代谢.
- YJYXF改变了肠道微生物群的多样性和组成,影响了三甲基胺N氧化物 (TMAO) 水平.
- 观察到肠道FXR和FGF-15的下调,以及肝脏CYP7A1表达的上调.
结论:
- 雅吉伊辛配方在改善ApoE小鼠的动脉样硬化方面表现出显著的有效性.
- 治疗效果与肠道微生物群,胆酸代谢和胆固醇通路的调节有关.
- YJYXF为心血管疾病,特别是动脉样硬化提供了一个有前途的治疗策略.
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