大肠直肠癌:选择液体活检标记物的应用
Maciej Skrzypek1, Aleksandra Joanna Binda1, Jacek Kabziński1
1Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland.
Polski przeglad chirurgiczny
|July 18, 2025
概括
液体活检为诊断和监测结直肠癌 (CRC) 提供了一种不那么侵入性的方法. 这种方法分析了像循环瘤DNA (ctDNA),循环瘤细胞 (CTC) 和外体细胞等生物标志物,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题,需要先进的诊断和监测工具.
- 传统的CRC活检是侵入性的,这促使人们研究更少的侵入性替代品,如液体活检.
研究的目的:
- 审查液体活检在结直肠癌诊断和治疗监测中的应用.
- 讨论用于CRC液体活检的关键生物标志物:ctDNA,CTC和外体.
主要方法:
- 对循环瘤DNA (ctDNA) 的分析.
- 检测和分析循环瘤细胞 (CTC).
- 基于外基因组的生物标志物评估.
主要成果:
- 液体活检提供实时瘤洞察力,与传统方法相比,降低了患者的入侵性.
- 生物标志物在早期CRC检测,预后和个性化治疗开发方面显示出潜力.
结论:
- 液体活检是瘤学的变革性工具,提高了CRC患者的生活质量和治疗疗效.
- 液体活检的持续发展有望显著改善结直肠癌的治疗.
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