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Updated: Sep 15, 2025

Author Spotlight: Understanding DNA Damage Response in Mammalian Oocytes and Preimplantation Embryos
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通过Pdha2对X结合的Pdha1沉默的补偿对于精子生成中中性双链断裂修复至关重要

Chen Pan1,2, Keisuke Shimada1, Hsin-Yi Chang1,3

  • 1Department of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka 5650871, Japan.

Development (Cambridge, England)
|July 18, 2025
PubMed
概括

丸特异性蛋白PDHA2对于男性生育能力至关重要. 在淘汰赛小鼠中缺少它会导致不孕症,因为它会损害雄性半导体过程中的能量代谢和DNA修复.

关键词:
亚精子缺血症 (Azoospermia) 是一种双链断裂修复 双链断裂修复介质变化 (Meiosis) 是一个过程.精子性染色体的性染色体不活化线粒体中的线粒体.鼠标 鼠标是一个鼠标.

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