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增强的OXPHOS和线粒体超极化在模拟微重力诱导的卵细胞成熟停止中的关键作用

Lei Ge^1,2,3, Yuqing Gao^1,3,4, Feifei Du^1,3

¹Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|July 18, 2025

概括

模拟的微重力通过破坏线粒体功能和组织来损害小鼠卵细胞成熟. 针对M相调节的干预措施显示,在太空中保持女性生育能力是有前途的.

科学领域:

生殖生物学生殖生物学
细胞生物学细胞生物学
空间生物学空间生物学

背景情况:

介质变化对于性繁殖至关重要.
微重力对卵细胞成熟的影响尚不清楚.
太空探索引发了人们对生殖健康的担忧.

研究的目的:

为了研究模拟微重力 (SMG) 对小鼠卵细胞成熟的影响.
为了确定SMG诱导的介质缺陷的潜在机制.
探索减轻这些影响的潜在策略.

主要方法:

暴露小鼠卵细胞到模拟微重力 (SMG).
评估线粒体功能 (氧化酸化,膜潜力).
分析介质性进展,螺旋组织和体积变.
对未折叠蛋白质反应和螺旋组装检查点 (SAC) 的研究.

主要成果:

SMG 损害了线粒体功能,导致介质性停止.
线粒体错位激活了展开的蛋白质反应,抑制了基因表达.
SMG延迟了微管组织中心 (MTOC) 凝聚,导致螺旋缺陷和形.
该SAC仍然是功能性的,表明线粒体功能障碍驱动介质加速.

结论:

线粒体功能障碍是SMG诱导的卵细胞中介质衰竭的一个关键因素.
SMG损害了卵子质量和发育潜力.
抑制酶促进复合体以延长I元相,改善了卵细胞成熟率.
在太空中,M相调节可能是保护女性生育能力的可行策略.

关键词:

扩展M阶段的M阶段时间.介质性进展介质性进展微管组织中心-微管组织中心.氧化酸化是一种氧化酸化.在模拟的微重力环境中进行模拟.

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