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Updated: May 5, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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基于深度学习的多模式融合方法用于预测急性皮肤毒性.

Monnishkaran Madheswaran1, Keerthana Jaganathan2, Lakshmanan Shanmugam1

  • 1Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu 600 127, India.

Journal of chemical information and modeling
|July 18, 2025
PubMed
概括

一个新的深度学习模型,TriModalToxNet,使用融合的分子数据准确地预测急性皮肤毒性. 这种多模式的方法为化学安全评估提供了比传统的动物试验更道德和更有效的替代方案.

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相关概念视频

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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