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相关概念视频

Olfaction01:25

Olfaction

45.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
45.2K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
9.6K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.6K

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相关实验视频

Updated: Sep 15, 2025

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

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优化气味剂的嗅觉训练基于嗅觉受体-连接体对对分析.

Hironobu Nishijima1, Eric H Holbrook2, James E Schwob3

  • 1Department of Otolaryngology-Head and Neck Surgery, The University of Tokyo, Tokyo, Japan.

The Laryngoscope
|July 18, 2025
PubMed
概括

与经典方法相比,一种新的四种气味剂组合显著增强了嗅觉受体 (OR) 刺激,提供了一种科学基础的方法来优化嗅觉训练 (OT) 以获得更好的结果.

关键词:
气味剂 气味剂是一种气味剂.嗅觉功能障碍 嗅觉功能障碍嗅觉受体是一种嗅觉受体.嗅觉训练是通过嗅觉训练进行的.受体连接体相互作用

更多相关视频

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing
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Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing

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相关实验视频

Last Updated: Sep 15, 2025

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

12.6K
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing
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Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing

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科学领域:

  • 嗅觉神经科学是一种神经科学.
  • 计算生物学是一种计算生物学.
  • 受体的药理学受体的药理学

背景情况:

  • 嗅觉训练 (OT) 用于改善嗅觉功能.
  • 目前的OT方法缺乏对气味选择的科学依据.
  • 优化OT需要了解嗅觉受体 (OR) 和气味相互作用.

研究的目的:

  • 为最大限度地刺激人类嗅觉受体确定最佳的气味组合.
  • 为了比较一种新型气味组合与经典OT气味组合的有效性.

主要方法:

  • 分析了来自M2OR数据库的75,050个OR-气味对实验.
  • 整合人类嗅觉表皮的转录数据,以识别高度表达的ORs.
  • 评估了与丰富的ORs的气味相互作用,以确定最佳组合.

主要成果:

  • 一种新的四种香料组合 (galaxolide,eugenol乙酸, [-]-menthol,geranyl乙酸) 刺激了83.9%的ORs,覆盖了69.9%的表达.
  • 经典的OT气味剂 (,,白,针) 刺激了39.2%的ORs,覆盖了32.9%的表达.
  • 这种新的组合提供了比经典气味剂更广泛的受体激活.

结论:

  • 基于受体的方法为优化嗅觉训练提供了科学基础的方法.
  • 这种新的气味组合显示出改善OT治疗疗效的潜力.
  • 需要进一步的临床验证来确认治疗效益.