来自Baijiu蒸商谷物的增值产品:生物活性黄酸和其潜在功能的评估
Jiao Li1, Jiayan Sun1, Yu Pan1
1College of Life Science, Shanxi University, Taiyuan, China.
Journal of food science
|July 18, 2025
概括
来自Baijiu蒸商谷物 (BDGs) 的黄类化合物显示出强大的抗氧化和抗衰老作用. 这项研究表明,它们有潜力延迟衰老并增强C. elegans.的抗压能力.
科学领域:
- 生物化学 生化学
- 老年学是指老年学的学科.
- 食品科学 食品科学 食品科学
背景情况:
- 巴吉乌蒸商的谷物 (BDG) 是巴吉乌造的大量副产品.
- 主要原料,富含生物活性黄,在造过程中聚焦在BDGs中.
研究的目的:
- 使用优化的乙醇辅助超声波方法从BDGs (BDF) 提取黄类.
- 评估BDF的体外和体外生物活性,重点关注抗氧化和抗衰老特性.
主要方法:
- 使用乙醇辅助超声波 (78分钟,40°C,47:1毫升/克,76%乙醇) 优化了BDF的提取.
- 在体外测定抗氧化剂和抗粉样纤维化活动.
- 使用Caenorhabditis elegans (C. elegans) 进行体内研究,以评估衰老延迟和抗压能力.
主要成果:
- 最佳提取结果为4.73 mg/g的BDF.
- 在实验室中,BDF表现出显著的抗氧化和抗粉样纤维化活性.
- 在C. elegans中,BDF延缓了衰老,增强了抗压能力,减少了活性氧物种 (ROS) 和蛋白质沉积,并通过HSF-1和SKN-1激活了抗氧化防御系统.
结论:
- BDF具有显著的抗氧化和抗衰老特性.
- 在体内,BDF激活了关键的应激反应通路 (HSF-1,SKN-1).
- BDF提出了一个有前途的战略,用于利用BDGs在抗衰老应用和增强耐药性.
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