树叶牙中的牙金属和微量元素:来自Project Viva项目的发现
Pi-I D Lin1, Christine Austin2, Yi Ying Ong3,4
1Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, United States.
Environmental science & technology
|July 18, 2025
概括
树叶牙精确地追踪了生命早期的金属暴露,母亲的血 (Pb) 水平与儿童牙Pb有很强的相关性. 种族和吸烟等母亲因素会影响这些金属度.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 毒理学 毒理学 毒理学
背景情况:
- 落叶牙提供了金属暴露的历史记录.
- 了解牙中的金属分布在人口水平上是有限的.
研究的目的:
- 在落叶牙中描述金属含量.
- 与牙内的金属测量进行比较.
- 评估母亲血液金属和儿童牙金属之间的关联.
- 评估母亲和儿童特征对金属水平的影响.
主要方法:
- 在Viva项目 (1999-2002) 中招募孕妇.
- 在随访期间 (2017-2020年) 收集的叶落牙.
- 分析了使用激光切除-诱导合的血质谱法 (LA-ICP-MS) 的牙金属度.
- 通过ICP-MS.测量了母亲的红细胞金属 (第一和第二个三个月).
- 使用Bland-Altman图表和交叉相关性比较重复的牙.
主要成果:
- 母体红细胞 (Pb) 和儿童牙Pb之间存在显著的正相关性.
- 最强的关联:第二个三个月的孕妇Pb和产前牙Pb (斯皮尔曼r = 0.78,p < 0.001).
- 金属度因母亲的种族,年龄,收入和吸烟情况而异.
结论:
- 落叶牙有价值,用于追踪生命早期的金属暴露.
- 母亲因素显著影响儿童牙中的金属含量.
- 需要进一步研究人口层面的金属分布和影响因素.
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