相关实验视频

Updated: Sep 15, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

素类的免疫调节作用强迫游泳诱导的免疫功能障碍在BALB/c小鼠

Ji-Eun Lee¹, Yunjung Lee², Seulbi Lim²

¹Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, Republic of Korea.

Journal of food science

|July 18, 2025

概括

蛋黄脂蛋白 (PPPs) 显示出管理运动诱导的免疫功能障碍的潜力. 这些化合物调节免疫细胞活性和细胞因子水平,建议在食品和制药中应用.

科学领域:

免疫学免疫学免疫学
生物化学生物化学
营养科学营养科学

背景情况:

免疫系统功能障碍增加了疾病的易感性.
免疫调节剂可以调节免疫反应.
来自蛋黄维的类具有有益的效果.

研究的目的:

为了研究卵黄衍生的维丁 (PPPs) 的免疫调节作用.
评估PPP对BALB/c小鼠强迫游泳引起的免疫功能障碍的影响.

主要方法:

使用高温和轻压 (HTMP) 预处理和酶水解来制备PPP.
在强迫游泳前的14天内,小鼠被口服PPP (200 mg/kg/d).
分析了免疫反应,包括淋巴细胞增殖,NK细胞活性,细胞因子水平,免疫球蛋白水平和氧化生产.

主要成果:

在炼过的小鼠中,PPP显著降低了脏T和B淋巴细胞的增殖.
PPP的管理增强了自然杀手 (NK) 细胞的细胞毒性.
PPPs调节了细胞因子 (IFN-γ,IL-2,IL-4,IL-6,IL-10),免疫球蛋白 (IgA,IgE,IgG) 和氧化 (NO) 的水平.

结论:

蛋黄衍生的脂 (PPPs) 显示出显著的免疫调节作用.
PPP有可能被开发为食品和制药行业的功能成分,以管理免疫功能障碍.

关键词:

细胞因子细胞因子强迫游泳强迫游泳免疫功能障碍免疫功能障碍免疫调节 - 免疫调节维酸的类类类.

更多相关视频

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

相关概念视频

Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...