肌纤维细胞蛋白质合成率在月经周期的低度和高度之间没有差异
Marianna C A Apicella1, Tom S O Jameson1, Alistair J Monteyne1
1Nutritional Physiology Research Group, Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK.
The Journal of clinical endocrinology and metabolism
|July 18, 2025
概括
整个月经周期内的雌激素水平不会显著影响女性的肌肉蛋白质合成率. 这项研究发现,尽管荷尔蒙波动,肌纤维细胞蛋白质合成没有差异.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 肌肉的新陈代谢
背景情况:
- 骨肌肉适应受性激素的影响,但月经周期期间雌醇波动对肌纤维蛋白合成 (MyoPS) 的影响尚不清楚.
- 了解这些荷尔蒙的影响对于优化训练和营养策略至关重要.
研究的目的:
- 为了比较月经周期的早期卵泡 (低 Estradiol) 和晚期卵泡 (高 Estradiol) 阶段的吸收后和食后运动后状态中的MyoPS率.
- 研究雌激醇对肌肉蛋白质合成的急性调节作用.
主要方法:
- 一个随机的交叉试验,涉及17名健康女性,比较月经周期的早期毛囊和晚期毛囊阶段.
- 在抵抗运动和氨基酸摄入后的4小时的食后运动后期,使用L-[环-2H5]-氨酸输注测量了MyoPS.
主要成果:
- 在月经周期的两个阶段,MyoPS的比率在运动后和氨基酸摄入增加,在早期和晚期的卵泡阶段之间没有明显的差异.
- 基因表达分析显示,与早期的卵泡相比,在晚期的卵泡阶段,蛋白质合成和肌肉重塑基因的表达增加.
- 在水平和整体MyoPS之间发现了适度的相关性.
结论:
- 较晚的卵泡阶段中雌激素度升高并没有提高肌纤维细胞蛋白质合成率.
- 雌激醇似乎不是急性调节肌肉质量的关键因素,eumenorrheic女性.
- 虽然基因表达表明肌肉生长的潜力,但MyoPS率不受急性雌激素波动的影响.
相关概念视频
01:22Hormonal Regulation of the Menstrual Cycle
704
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
704
01:30Hormonal Control of the Ovarian Cycle
3.0K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
3.0K
01:27Ovarian Cycle
1.9K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.9K