无机酸盐对内皮功能的影响:随机对照试验和元分析的系统审查
Begum Celik1,2, Esther Muriuki1, Gunter G C Kuhnle1
1Hugh Sinclair Unit of Human Nutrition, School of Chemistry, Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, United Kingdom.
Nutrition reviews
|July 18, 2025
概括
无机酸盐补充剂显著改善内皮功能,通过流介导扩张 (FMD) 测量. 这一发现表明,预防心血管疾病具有临床相关的益处.
科学领域:
- 心血管研究研究心血管研究
- 内皮细胞功能 内皮细胞功能
- 氧化的代谢 氧化的代谢
背景情况:
- 无机酸盐是氧化 (NO) 的前体,是血管平衡的关键调节剂.
- 内皮功能障碍是心血管疾病的重要危险因素.
- 酸盐-酸盐-NO通路在维持血管健康方面发挥着至关重要的作用.
研究的目的:
- 系统地审查和元分析无机酸盐对内皮功能的影响.
- 为了评估与对照组相比,在消耗无机酸盐后,流介导扩张 (FMD) 的变化.
- 评估无机酸盐在预防心血管疾病方面的临床相关性.
主要方法:
- 在Medline,Web of Science和Scopus数据库中的系统文献搜索.
- 使用随机效应模型对13项随机对照试验的元分析.
- 使用Cochrane偏差风险工具评估研究质量的评估.
主要成果:
- 无机酸盐的消费与口病的显著改善有关 (SMD 1.48%,P < 0.01),并观察到高异质性.
- 对口病的有益影响在不同剂量,持续时间,健康状况和酸盐类型中是一致的.
- 与慢性摄入相比,急性酸盐摄入显示出更大的口炎反应.
结论:
- 无机酸盐补充剂显著提高内皮功能 (FMD) 超过1%.
- 这种改善代表了预防心血管疾病的临床相关幅度.
- 虽然有希望,但鉴于某些研究中的异质性和偏见风险,进一步的高质量研究是有必要的.
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