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长期太空飞行后小鼠肺组织的转录基因变化

D A Yakubets1, Yu V Rudimova1, L B Buravkova2

  • 1Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.

Bulletin of experimental biology and medicine
|July 18, 2025
PubMed
概括
此摘要是机器生成的。

长期航天改变了小鼠肺部的基因表达,一些嗅觉基因意外增加,蛋白质折叠/昼夜节律基因减少. 肺细胞显示低重力敏感性和高适应性.

关键词:
不同的基因表达.肺组织的肺组织组织.在微重力环境中,微重力太空飞行 太空飞行 太空飞行

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科学领域:

  • 太空生物学空间生物学
  • 分子生物学分子生物学
  • 基因组学就是基因组学.

背景情况:

  • 太空飞行会在多个器官系统中引发显著的生理适应.
  • 了解分子机制,特别是转录变化,对于阐明这些适应微重力的变化至关重要.

研究的目的:

  • 为了研究长期太空飞行后小鼠肺组织的转录组概况.
  • 为了确定长期暴露于无重量/微重力所影响的特定基因和途径.

主要方法:

  • 从长期太空任务中获得的小鼠肺组织的分析.
  • 转录形状分析以识别差异表达的基因.

主要成果:

  • 在肺组织中鉴定出45个不同表达的基因.
  • 观察到G蛋白结合的嗅觉和鼻受体基因的"异位"上调.
  • 发现了参与蛋白质折叠和昼夜节律调节的基因的下调.

结论:

  • 肺细胞对重力的敏感性很小.
  • 鼠标肺组织在长时间的太空飞行中表现出高度的适应潜力.
  • 转录转移提供了关于细胞在空间中的适应机制的见解.