药物遗传学研究中的生活质量措施:系统性审查
Shen Chi Ng1, Nathan He1, Patrick Fu1
1Health Economics and Policy Evaluation Research (HEPER) Group, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia.
概括
药物遗传学研究使用了许多不同的生活质量 (QoL) 工具,使得结果难以比较. 未来的研究需要一致的QoL测量选择和报告,以获得可靠的结果.
科学领域:
- 药物基因组学 药物基因组学
- 健康 结果 研究 研究 结果
- 临床试验方法论 临床试验方法论
背景情况:
- 生活质量 (QoL) 在药物遗传学研究中越来越多地被评估.
- 关于该领域最常使用的QoL工具存在缺乏清晰度.
- 这项研究解决了关于药物基因组学中QOL工具选择的证据缺口.
研究的目的:
- 系统地识别和分类在药物基因组学研究中使用的生命质量 (QoL) 措施.
- 在药物遗传学文献中分析QOL工具的多样性和应用.
主要方法:
- 在主要数据库 (PubMed,Cochrane图书馆,Embase,Ovid) 进行了全面的系统审查,截至2024年4月.
- 搜索术语包括"药物遗传学"与各种生活质量和健康实用术语相结合.
- 纳入标准侧重于随机临床试验,队列研究和评估药物基因组学中的QoL的横截面研究.
主要成果:
- 十二项研究符合纳入标准,使用了一系列QOL工具,包括EORTC QLQ-C30,SF-36,SF-12,WHOQOL-BREF和FACT-Melanoma.
- 确定的工具包括通用 (例如,SF-36) 和疾病特异性 (例如,FACT-黑色素瘤) 的措施.
- 一个重要的发现是没有理由选择QOL工具,并且在各个研究中报告结果不一致.
结论:
- 药物遗传学研究显示,在选择和应用QOL仪器方面存在相当大的异质性.
- 这种多样性阻碍了对QOL结果的一致和可靠的报告.
- 建议包括证明QOL工具选择的合理性和标准化结果报告,以提高可比性和决策.
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