基于正念的干预措施对炎症的有效性:系统性审查和元分析
Xiaohong Huang1, Jing Lv2, Dongxu Zhu3
1Shandong Institute of Traumatic Orthopedics, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Biogerontology
|July 18, 2025
概括
基于正念的干预措施 (MBI) 有效地降低了IL-6,TNF-α和CRP等炎症标志物. 替代性MBI显示出更有希望的减轻与年龄相关的炎症和改善健康指标.
科学领域:
- 老年学是一门学科.
- 心理神经免疫学 心理神经免疫学
- 综合医学是一个整体的医学.
背景情况:
- 炎症是一种与衰老和疾病相关的慢性轻度炎症,其特点是炎症标志物 (IL-6,TNF-α,CRP) 和改变的衰老指标 (TA,TL,PWV,FMD) 的升高.
- 基于正念的干预措施 (MBI) 被认为可以通过意识和接受来促进福祉,但它们对炎症的具体影响需要进行系统的评估.
研究的目的:
- 系统地评估 MBIs 对与炎症相关的生物标志物的影响.
- 评估MBI和炎症标志物之间的因果关系的证据.
主要方法:
- 在主要数据库 (PubMed,Web of Science,Cochrane,ProQuest) 进行了全面的文献搜索,搜索到2024年3月之前发表的研究.
- 包括的研究是随机对照试验 (RCT) 和涉及成人的前后试验,重点是MBIs和炎症生物标志物.
- 使用标准化平均差异的元分析 (RCT的莫里斯dppc,前后的科恩d) 进行了量化干预效应.
主要成果:
- 风险试验表明TNF-α,IL-6,CRP和PWV的显著减少,随着MBI后的口病,TL和TA的增加.
- 前后试验证实了这些发现,显示TNF-α,IL-6和CRP的减少.
- 不仅限于主流实践的替代MBIs在降低IL-6和CRP方面更有效,而MBIs在患病人群中降低TNF-α方面表现特别有效.
结论:
- 从RCT和前后试验中获得的中度确定性证据支持MBI和减少炎症标志物之间的因果关系.
- 探索非主流的MBI可能为减轻与年龄相关的炎症提供更好的好处.
- MBIs代表了一种有前途的非药物治疗方法来对抗炎症及其相关的健康风险.
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