急性胰腺炎:将早期机制转化为临床管理
1Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, 500 082, India. rup_talukdar@yahoo.com.
概括
早期急性胰腺炎 (AP) 涉及素激活和炎症,导致器官损伤. 肠道屏障,微生物群和淋巴细胞也显著影响AP的严重程度和感染风险.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 急性胰腺炎 (AP) 是一个重大的临床挑战,没有治愈的早期治疗.
- 早期的AP病变包括内的试原激活,内细胞损伤和随后的炎症.
- 系统性炎症反应综合征 (SIRS) 和补偿性抗炎反应综合征 (CARS) 导致器官损伤和免疫抑制.
研究的目的:
- 审查当前对早期AP机制的理解.
- 讨论早期AP病变的临床影响.
- 为了突出肠道在AP严重性中的作用.
主要方法:
- 这是一个叙事评论.
- 关于早期AP机制和临床影响的文献搜索.
- 专注于胰腺内事件,全身反应和肠道贡献.
主要成果:
- 早期的AP通过DAMP和免疫细胞激活触发局部炎症,导致SIRS.
- 发展到CARS,导致免疫抑制和易受感染的感染,如感染性瘤.
- 肠道屏障功能障碍,失生症和肠道淋巴细胞有助于全身炎症和严重性.
结论:
- 了解早期的AP机制对于开发有效疗法至关重要.
- 肠道因素在AP的进展和结果中发挥着关键作用.
- 针对早期的炎症和肠道事件可能会改善AP管理.
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