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离子渐变驱动的药物加载脂质体用于shikonin/regorafenib的配送,用于癌症免疫代谢疗法和术后干预

Xinyue Shao^1,2,3, Taoxing Peng^1,4, Chenxiao Yang^1,5

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Rd, Shanghai 201203, China.

ACS applied materials & interfaces

|July 18, 2025

概括

这项研究开发了一种T12改性脂质体 (T12-SR-LP) 来输送什科宁和雷戈拉费尼布,有效向瘤乳酸代谢和免疫抑制. 这种新的配方抑制了瘤生长和"冷"瘤的复发.

科学领域:

免疫代谢过程中的免疫代谢.
癌症治疗癌症治疗
纳米医学是一种纳米医学.

背景情况:

乳酸盐通过使巨细胞偏向M2表型并激活免疫抑制细胞来促进瘤的进展.
向内乳酸是一种对免疫沙漠瘤的有希望的策略.
石康宁 (SHK) 通过向酸盐激酶M2 (PKM2) 来抑制乳酸盐的产生.
雷戈拉菲尼布 (REGO) 从M2到M1表型的瘤相关巨细胞 (TAMs) 再极化.

研究的目的:

为SHK和REGO开发一个有针对性的交付系统,以克服其临床局限性.
为了研究一种新型脂肪体配方在对抗"冷"瘤中的有效性.

主要方法:

通过离子梯度方法构建了一个T12改性脂质体 (T12-SR-LP),通过离子梯度方法封装SHK和REGO.
利用铜离子介导的协调来提高药物加载效率.
将T12-SR-LP配制成水凝 (T12-SR-LP@Gel) 用于局部输送.
在临床前模型中评估瘤生长和复发抑制.

主要成果:

T12-SR-LP实现了高的总药物加载效率10.5%,达到10.5%.
与对照组相比,T12-SR-LP@Gel显著抑制了瘤生长和复发.
该配方有效地针对瘤微环境的代谢和免疫方面.

结论:

T12-SR-LP代表了一种有前途的纳米医学策略,用于治疗"冷"瘤.
双重向的方法解决了乳酸驱动的免疫抑制,并增强了抗瘤免疫力.
这种方法为免疫反应差的瘤提供了潜在的治疗途径.

关键词:

组合疗法是一种联合疗法.离子梯度药物加载的药物加载乳酸盐是一种乳酸盐.在西康尼尼 (Shikonin) 书房里.瘤微环境是一个微环境.

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