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Updated: Sep 14, 2025

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在基因组编辑中,由Cas-sgRNA-DNA复合体的内在特性驱动的非目标序列变异

Celine Kurniawan1, Takeshi Itoh1,2

  • 1Master Program in Global Agriculture Technology and Genomic Science, International College, National Taiwan University, Taipei, Taiwan.

PloS one
|July 18, 2025
PubMed
概括

了解基因组编辑非目标突变对于安全至关重要. 这项研究揭示了内在的Cas-sgRNA-DNA复杂性质在很大程度上决定了目标外模式,为改进的计算预测工具铺平了道路.

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