使用机器学习来识别基于血液的生物标志物与种族和种族之间的后期生活健康之间的关联的差异
Mateo P Farina1, Eric T Klopack2, Eileen M Crimmins2
1Department of Human Development and Family Science and the Population Research Center, University of Texas at Austin, Austin, Texas, United States.
概括
预测老年人健康状况的机器学习模型可能过度代表白人人口. 在死亡率方面,生物标志物选择在种族/族群之间有显著的差异,但在其他疾病方面则差异较小,这凸显了包容性GeroScience研究的必要性.
科学领域:
- 吉罗科学 吉罗科学 吉罗科学
- 生物标志物 生物标志物
- 机器学习 机器学习
背景情况:
- 生物标志物和机器学习越来越多地用于预测老年人的健康状况.
- 当前的预测算法可能会偏爱与大多数人口相关的生物标志物,可能会忽视种族/民族差异.
- 了解生物标志物选择中的种族/民族差异对于公平的GeroScience研究至关重要.
研究的目的:
- 调查预测健康结果的生物标志物选择在种族/族群之间如何不同.
- 在老龄化研究中用于生物风险评分的机器学习模型中识别潜在的偏差.
主要方法:
- 利用了健康与退休研究的2016年静脉血液子研究 (VBS) 的数据.
- 采用种族分层增强的决策树模型,使用54个生物标志物预测全因死亡率,多病症,糖尿病和心脏病.
- 基于特征值的生物标志物选择中的种族/种族差异可视化.
主要成果:
- 在种族/族群之间观察到生物标志物选择的显著差异,用于所有原因死亡率预测.
- 对于心脏病和糖尿病,生物标志物选择的变化有限.
- 多发病率显示出一些变化,但在各组之间存在相当大的重叠.
结论:
- 机器学习对生物风险评分提供了对衰老的洞察力,但需要仔细考虑种族/民族差异.
- 对于健康预测的生物标志物选择因种族/种族和健康结果类型而异.
- 未来的GeroScience研究必须解决这些差异,以准确和公平的健康评估.
更多相关视频
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
1.5K
12:18A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
7.6K
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
331
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
331
Longitudinal Research
12.4K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.4K
Genome-wide Association Studies-GWAS
14.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.1K
