细菌补充剂对死菌肠炎挑战的 brojlers 的表现,肠道健康和血液生物化学的影响
Muhammad Muneeb1, Ehsaan Ullah Khan1, Saima1
1Department of Animal Nutrition, Faculty of Animal Production and Technology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Research in veterinary science
|July 18, 2025
概括
菌体治疗有效地通过改善生长和减少肠道损伤来对抗 brojlers 中的死肠炎. 这种无抗生素的方法对家禽的健康和表现有显著的前景.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物健康 动物健康
- 微生物学 微生物学
背景情况:
- 由Clostridium perfringens (CP) 引起的死肠炎 (NE) 严重影响肉生产,特别是在抗生素受限制的系统中.
- 菌体治疗为控制家禽中CP等肠道病原体提供了潜在的抗生素替代品.
- 有限的体内数据存在于菌体与益生菌相结合,针对导致肉NE的CP菌株.
研究的目的:
- 为了评估含有细菌素细菌和菌体的细菌制剂 (PathoGoneTM-DWA) 对 brojler的NE的疗效.
- 在挑战条件下评估细菌补充对 brojler 性能,肠道健康和生理参数的影响.
主要方法:
- 576只Ross-308雄被分为四组:负控,正控,低剂量菌和高剂量菌.
- 鸟类受到菌菌和一个NetB阳性Clostridium perfringens型G野外菌株的挑战.
- 细菌准备剂通过饮用水以不同的剂量进行了施用.
主要成果:
- 菌体补充剂显著改善了料摄入量,体重增加和料转化率 (P < 0.05).
- 在接受菌体治疗的组中,观察到肠道损伤得分和死亡率降低.
- 组织形态学,血液学指数和血清生物化学显示NE相关损伤和异常的显著恢复 (P <0.05).
结论:
- 细菌补充剂 (PathoGoneTM-DWA) 有效地改善了NetB阳性CP的 brojlers的性能指标.
- 治疗缓解了肠道损伤,并恢复了血液学和生化学障碍.
- 这突显了菌体治疗作为针对性,无抗生素干预针对家禽死肠炎的有效性.
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