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Updated: Sep 14, 2025

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ZNF207驱动的PRDX1乳酸和NRF2激活在雷戈拉费尼布耐药性和铁死回避中的作用

Tianfeng Yang1, Suyu Zhang1, Kun Nie1

  • 1School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, PR China; State Key Laboratory of Shaanxi for Natural Medicines Research and Engineering, Xi'an 710061, PR China.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
|July 18, 2025
PubMed
概括

指蛋白207 (ZNF207) 通过抑制铁亡,在肝癌中驱动对Regorafenib (RGF) 的耐药性. 准ZNF207-PRDX1-NRF2通路可以恢复RGF的敏感性,并提供新的治疗策略.

关键词:
铁化是铁化的一种.肝细胞癌是肝细胞癌.在PRDX1中,乳酸化.对雷戈雷费尼布的耐药性在ZNF207中,它是ZNF207.

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