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Updated: Apr 13, 2026

In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
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集成的单细胞和空间转录组学揭示了与胰腺癌神经入侵有关的独特细胞亚型

Min-Min Chen1, Qinhang Gao2, Huiheng Ning1

  • 1Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, China.

Cancer cell
|July 18, 2025
PubMed
概括

这项研究揭示了神经如何与胰腺癌相互作用,确定了驱动癌症入侵和恶化患者生存的TGFBI+施万细胞等特定细胞. 了解这些神经相互作用对于开发新的胰腺癌治疗方法至关重要.

关键词:
没有,没有,没有,没有.我们的PDAC是PDAC.施万的细胞是斯万的细胞.这就是TLSs.在TME中,它是最重要的.体内膜纤维细胞.神经侵袭是一种神经侵袭.神经免疫瘤学神经免疫瘤学胰腺管道腺癌瘤一个单细胞RNA序列的RNA序列.空间转录学 空间转录学三级淋巴体结构的第三级淋巴体结构瘤微环境是一个微环境.与瘤相关的神经.

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Cancer Cell Migration through Invadopodia01:35

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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