甲状腺癌患者骨转移的预后因素和生存结果:基于人口的队列研究的见解
Hang Zhao1, Xiao-Zhun Tang2, Duo-Ping Wang2
1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
概括
年龄,形甲状腺癌 (TC) 和其他转移部位显著影响骨转移 (BM) 患者的存活率. 放射性同位素治疗是TCBM癌症特异性生存的关键因素.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 癌症转移 癌症转移
背景情况:
- 甲状腺癌 (TC) 是最常见的内分泌恶性瘤.
- 骨转移 (BM) 是TC的常见并发症,与预后不佳有关.
- 有限的研究存在于TCBM的预后因素.
研究的目的:
- 评估甲状腺癌和骨转移 (TCBM) 患者的预后因素和生存结果.
主要方法:
- 利用了TCBM患者的监测,流行病学和最终结果 (SEER) 数据库中的数据.
- 采用单变量和多变量Cox比例危险回归模型来确定生存预测因素.
- 使用Kaplan-Meier方法和日志等级测试计算的生存结果.
主要成果:
- 包括696名TCBM患者 (2010年至2021年).
- 降低整体存活率的因素:年龄≥55,形性TC,脑/肝/肺转移,T4阶段.
- 癌症特异性生存的因素:阿纳普拉斯TC,肝/肺转移和放射性同位素治疗.
结论:
- 年龄,病理亚型,转移性病变和放射性同位素治疗对TCBM的预后有重大影响.
- 调查结果有助于合理的治疗决策和TCBM患者的风险分层.
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