从障碍到突破:中孔二氧化纳米颗粒在向瘤微环境中的作用
Adel Mahmoudi Gharehbaba1, Fatemeh Soltanmohammadi2, Morteza Eskandani3
1Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
International journal of pharmaceutics
|July 18, 2025
概括
半孔纳米粒子 (MSN) 可以克服瘤微环境 (TME) 的障碍. 这些纳米颗粒提供了一个多功能平台,以增强癌症药物输送和免疫治疗的有效性.
科学领域:
- 纳米技术纳米技术
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
背景情况:
- 瘤微环境 (TME) 显著影响癌症的进展,转移和抗治疗能力.
- 对瘤的有效药物输送受到TME内的生理和生化障碍所阻碍.
研究的目的:
- 审查TME在癌症进展中的作用.
- 探索介质纳米粒子 (MSNs) 作为调节TME的药物递送平台.
- 突出基于MSN的策略,以克服TME挑战并增强癌症治疗.
主要方法:
- 关于MSN及其在癌症治疗中的应用的当前文献的综述.
- 对TME调制的MSN策略的分析,包括低氧减轻,pH正常化和向树皮细胞.
- 评估MSN在抑制华堡效应和改善免疫治疗方面的潜力.
主要成果:
- MSN具有有利的特性,如高表面积和可调节的孔径大小,用于药物输送.
- 基于MSN的策略可以有效地解决与TME相关的挑战,例如缺氧,酸性和异常血管系统.
- 在向癌症相关纤维细胞 (CAFs) 和瘤相关巨细胞 (TAMs) 方面,MSNs显示出前景.
结论:
- MSN代表了一个高度适应的平台,可以提高癌症治疗的特异性和有效性.
- 通过重新配置TME,MSN在推进个性化癌症治疗方面具有重大潜力.
- 对基于MSN的治疗方法的进一步研究可能会彻底改变癌症治疗策略.
相关概念视频
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K