与mRNA-1273的COVID-19疫苗接种者相比,对IgG2和IgG4的类切换在BNT162b2中更加明显
Alex S Siebner1, Johanna Griesbaum2, Kelsey E Huus3
1Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research, Partner Site Tübingen, Germany.
概括
与mRNA-1273 (Moderna) 相比,用BNT162b2 (Pfizer/BioNTech) 进行的补充疫苗引发了较高的IgG2和IgG4抗体水平. 这些针对SARS-CoV-2疫苗的特殊差异可能会影响长期免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 接种SARS-CoV-2疫苗会产生抗体,这对于减少严重疾病至关重要.
- 不同的免疫球蛋白G (IgG) 亚类对补体激活,Fc受体结合和病毒中和具有不同的能力.
- 了解特定平台的IgG亚类反应对于评估疫苗疗效至关重要.
研究的目的:
- 为了比较BNT162b2与mRNA-1273.3接种后的IgG亚类反应,用BNT162b2对抗mRNA-1273.
- 调查先前疫苗接种史对后增剂IgG子类概况的影响.
主要方法:
- 一个多重免疫试验量化了IgG1,IgG2,IgG3和IgG4结合抗体对抗SARS-CoV-2抗原.
- 在接受了BNT162b2或mRNA-1273的增强剂后,从165名健康人群中采集了样本,这些人之前已经接种了两剂疫苗.
- 对抗体反应的特异性被分析为针对三聚体尖端蛋白,受体结合域和S1/S2子单元的特异性.
主要成果:
- 辅助疫苗接种增加了大多数IgG子类水平,但S1特异性IgG1和S2特异性IgG2.2的例外值得注意.
- 与mRNA-1273疫苗接种相比,在BNT162b2接种后观察到显著更高的IgG2和IgG4水平.
- 之前接受过非mRNA疫苗接种的个体在增强后IgG2或IgG4的水平没有显著增加.
结论:
- 在增剂接种疫苗后,在IgG子类反应中发现了明显的疫苗特异性差异.
- 这些变化可能会影响IgG2和IgG4之间的类切换.
- 在IgG子类的细微差异可能会影响长期免疫力和对SARS-CoV-2的保护.
关键词:
一个IgG子类的IgG子类.在IgG2的基础上,IgG2在IgG4的基础上,IgG4多重免疫试验 (Multiplex immunoassay) 是一种多重免疫试验.这就是SARS-CoV-2病毒.这是mRNA疫苗.更多相关视频
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