听力损失的特定年龄,性别和祖先的患病率在英国生物银行和我们所有人的研究计划中
Jun He1,2, Sharon G Curhan3,4, Gary C Curhan3,4
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Aging and disease
|July 18, 2025
概括
听力损失 (HL) 影响英国生物库的28%和我们所有人的16%,患病率因年龄,性别和祖先而异. 在不同的人群中,听力损失的性别差异是显著的.
科学领域:
- 遗传学和流行病学
- 公共卫生 公共卫生
- 听力学 听力学是指听力学.
背景情况:
- 听力损失 (HL) 代表了全球健康的重大负担.
- 关于不同祖先群体中HL流行情况的数据有限.
- 了解这些差异对于有针对性的公共卫生干预至关重要.
研究的目的:
- 调查听力损失的年龄,性别和祖先特异性流行情况.
- 为了比较英国生物库 (UKB) 和我们所有人研究计划 (AoU) 队列之间的HL患病率.
- 为了确定特定人口的风险因素和听力损失的趋势.
主要方法:
- 分析了来自UKB和AoU的827,406名参与者.
- 使用电子健康记录和自我报告数据定义的HL.
- 在人口分组中计算年龄标准化流行率.
主要成果:
- 整体HL患病率:在UKB占28%,在AOU占16%.
- 观察到显著的性别差异,男性普遍患病率较高,除了特定的非洲血统群体.
- 欧洲血统的患病率最高,非洲和亚洲血统群体的患病率最低.
结论:
- 听力损失的患病率因性别和祖先而异.
- 在HL的性别差异必须在不同的人口背景下进行解释.
- 调查结果强调了包容性研究和个性化听力保健策略的必要性.
相关概念视频
Genome-wide Association Studies-GWAS
14.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.3K
Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Unrenewable Cells
2.4K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.4K
Hearing
53.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
53.1K
Prevalence and Incidence
821
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
821


