在前1000天的营养干预和长期健康结果:系统性审查
Anna Xu1,2,3, Kathrin Guerlich1,2, Berthold Koletzko4,5
1Division of Metabolic and Nutritional Medicine, Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU University Hospital, Munich, Germany.
早期营养计划有望改善儿童的心脏代谢健康和饮食习惯. 然而,大多数研究都缺乏长期跟踪,这凸显了对持久健康影响的更多研究的需要.
科学领域:
- 儿童营养学 儿童营养学
- 公共卫生干预 公共卫生干预
- 纵向健康研究 纵向健康研究
背景情况:
- 早期的营养对长期的健康状况有很大影响.
- 在最初的1000天内进行营养干预对儿童发育至关重要.
- 本综述评估了早期营养计划对儿童健康的长期影响.
研究的目的:
- 系统地审查营养干预措施在最初1000天对长期健康的影响.
- 评估对心脏代谢,呼吸和精神健康以及饮食行为的影响.
- 确定早期营养研究的长期结果报告中的研究差距.
主要方法:
- 来自高收入国家的随机对照试验 (RCT) 的系统审查.
- 搜索了四个数据库和两个试验注册表,更新时间为2020年和2022年.
- 使用Cochrane工具评估偏差风险和使用GRADE的结果确定性.
主要成果:
- 包括来自63篇文章的20项干预措施,主要从婴儿期开始.
- 观察到一些对心脏代谢健康和饮食行为的积极影响.
- 没有发现对心理健康的显著影响,也没有报告呼吸系统健康结果.
结论:
- 早期营养干预往往缺乏长期跟踪,并报告各种结果.
- 有证据表明,对心脏代谢健康和饮食行为有潜在的益处.
- 为了有效的干预计划,需要进一步研究长期,临床相关的结果.
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