血管年龄之间的比较基于手腕-脚脉冲波速或带-股骨脉冲波速
Tianhui Dong1,2, Fangfang Fan3,4,5, Hongyu Chen1,2
1Department of Cardiology, Peking University First Hospital, Beijing, China.
概括
使用脚脉冲波速率 (baPWV) 计算的血管年龄更好地预测心血管事件,而不是带骨脉冲波速率 (cfPWV). 由baPWV引起的早期血管衰老显著增加了心血管风险,为大规模风险预测提供了有价值的工具.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 流行病学 流行病学
背景情况:
- 血管年龄 (VA) 可以提高超越时间年龄的心血管风险预测.
- 对比计算VA的不同方法对于临床应用至关重要.
研究的目的:
- 为了确定哪种血管年龄测量,腕脉冲波速率 (baPWV) 或带骨脉冲波速率 (cfPWV),与心血管事件风险更强烈相关.
- 评估早期血管衰老 (EVA) 对心血管事件的预测价值.
主要方法:
- 在中国北京,对5723名参与者的前性队列研究.
- 血管年龄 (VA) 用多变量回归模型与脉冲波速度 (baPWV或cfPWV) 和心血管风险因素计算.
- ∆-年龄 (VA的残留在时间年龄上) 用于定义超正常,正常和早期的血管衰老类别.
主要成果:
- 在对年龄和性别进行调整后,baPWV的∆-年龄与心血管风险显著相关 (HR:1.05).
- 在对传统风险因素进行调整后,baPWV定义的早期血管衰老组与正常血管衰老相比,显著增加了心血管风险 (HR:1.84),与正常血管衰老相比.
- 根据cfPWV计算的VA,没有发现显著的关联.
结论:
- 通过baPWV计算的血管年龄是大群体中心血管疾病风险预测的宝贵工具,因为它的简单性和便利性.
- baPWV衍生的VA,特别是早期血管衰老的概念,提供了更好的心血管风险分层.
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