对于颗粒细胞神经元前体的发展和Sonic Hedgehog Medulloblastoma生长,需要SMARCA5

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Updated: Sep 14, 2025

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

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Foteini Tsiami1,2, Layla Drwesh3, Surender Surender1,2

  • 1Department of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.

Scientific reports
|July 18, 2025
PubMed
概括

研究人员确定SMARCA5是Sonic hedgehog medulloblastoma (SHH-MB) 中的一个关键遗传依赖. 向SMARCA5可以抑制瘤生长,并改善小鼠模型的存活率,突出其在小脑发育和SHH-MB病变发生中的作用.

关键词:
这就是SMARCA5的标志.大脑小叶的发展.颗粒神经元前体的前体.索尼克子中枢细胞瘤 索尼克子中枢细胞瘤

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