氧调节蛋白150可以被视为阻塞性睡眠呼吸暂停的严重性指标
Önder Otlu1, Mehmet Erdem2, Tuğba Raika Kıran2
1Department of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Turkey. onder.otlu@ozal.edu.tr.
Scientific reports
|July 18, 2025
概括
氧调节蛋白150 (ORP150) 的血清水平在阻塞性睡眠呼吸暂停 (OSA) 患者中升高. 较高的ORP150水平与OSA严重程度相关,表明其作为诊断标记物的潜力.
科学领域:
- 生物化学 生物化学
- 睡眠医学 睡眠医学
- 细胞生物学 细胞生物学
背景情况:
- 氧调节蛋白150 (ORP150) 是由细胞压力诱导的内分泌网膜伴侣.
- 在缺氧和ER压力等条件下,ORP150表达增加,提供细胞保护.
- 它在阻塞性睡眠呼吸暂停 (OSA) 中的作用,这是一种涉及间歇性缺氧的疾病,尚不清楚.
研究的目的:
- 在不同程度的阻塞性睡眠呼吸暂停 (OSA) 患者中检查血清ORP150水平.
- 确定血清ORP150是否可以作为OSA的诊断标记,并与疾病严重程度相关.
主要方法:
- 从49名OSA患者 (25例严重,24例轻度至中度) 和23名健康对照人群中采集了血清样本.
- 酶相关免疫吸收试验 (ELISA) 用于量化血清ORP150水平.
- 采用接收器操作特征 (ROC) 分析来评估ORP150.0.的诊断效用.
主要成果:
- 在所有组中观察到血清ORP150水平的显著差异 (严重的OSA:8.03 ng/mL,轻度至中度的OSA:5.54 ng/mL,对照:4.41 ng/mL).
- 血清ORP150水平与OSA严重程度有直接的相关性.
- 7.14 ng/mL的ORP150截止值证明了OSA的诊断能力.
结论:
- 与对照组相比,OSA患者的血清ORP150水平显著升高.
- ORP150水平与阻塞性睡眠呼吸暂停的严重程度相关.
- 血清ORP150可以作为OSA及其严重程度的有价值的差异诊断参数.
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