自艾滋病毒诊断以来的时间与艾滋病毒感染的老年人内存轻度认知障碍 (MCI) 有关
Jason S DeFelice1, Mark K Britton2,3, Yancheng Li3
1Center for Cognitive Aging and Memory, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA. jdefelice@phhp.ufl.edu.
Journal of neurovirology
|July 18, 2025
概括
携带艾滋病毒的老年人面临较高的轻度认知障碍 (MCI) 风险,特别是遗忘性MCI (aMCI). 长时间的艾滋病毒和延迟治疗与aMCI相关,这表明累积的艾滋病毒暴露会影响大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 老年学是指老年学的学科.
背景情况:
- 艾滋病毒 (PWH) 感染的老年人患轻度认知障碍 (MCI) 的风险增加.
- 亚型包括遗忘性MCI (aMCI) 和非遗忘性MCI (naMCI).
- 了解PWH中MCI的风险因素对于早期干预至关重要.
研究的目的:
- 检查风险因素 (HIV变量,物质暴露,APOE基因型) 和老年PWH中临床医生定义的MCI之间的关联.
- 评估临床医生共识和算法aMCI分类之间的一致性.
- 评估aMCI和艾滋病毒相关的神经认知障碍 (HAND) 之间的重叠.
主要方法:
- 56名老年PWH (平均年龄63岁) 接受了神经认知测试.
- 建立了临床医师共识诊断 (aMCI,MMCI,没有MCI).
- 评估的风险因素包括艾滋病毒持续时间,护理时间,物质暴露,APOE基因型和病毒载量;还进行了算法 aMCI 和 HAND 分类.
主要成果:
- 36%的参与者符合共识aMCI标准.
- aMCI与艾滋病毒诊断以来的持续时间更长,护理时间延迟和阿片类药物暴露显著相关.
- MCI与酒精,可卡因,大麻,APOE基因型或可检测的病毒载量无关;临床医生和算法aMCI之间发现了实质性的协议.
结论:
- 较长的累积艾滋病毒暴露,根据诊断后的时间和护理时间,与老化PWH中的amnestic MCI有关.
- 这些发现表明,累积艾滋病毒暴露对老年PWH的认知功能有潜在的神经病理影响.
- 需要进一步的研究来探索这种人群认知能力下降的机制和干预措施.
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