2型糖尿病患者和没有2型糖尿病患者的体重指数和感染风险:使用电子健康记录的队列研究
Iain M Carey1, Tess Harris2, Umar A R Chaudhry2
1Population Health Research Institute, St George's School of Health and Medical Sciences, City St George's, University of London, London, SW17 0RE, UK. sgjd450@sgul.ac.uk.
International journal of obesity (2005)
|July 18, 2025
概括
患有2型糖尿病的人面临更高的感染风险. 然而,身体质量指数 (BMI) 对糖尿病患者和没有糖尿病患者的感染风险的影响相似,体重不足和肥胖都增加了易感性.
科学领域:
- 代谢障碍和传染性疾病
- 肥胖和公共卫生问题
- 慢性疾病的流行病学.
背景情况:
- 观察性研究表明,身体质量指数 (BMI) 和感染风险之间存在U形关系.
- 患有2型糖尿病 (T2D) 的人往往患有肥胖症,并且感染感染的风险增加.
- 与非糖尿病患者相比,BMI对T2D患者感染风险的具体影响尚不清楚.
研究的目的:
- 研究BMI与2型糖尿病 (T2D) 患者和没有2型糖尿病 (T2D) 患者的感染风险之间的关联.
- 为了确定BMI-感染风险关系是否在T2D患者和一般人群之间有所不同.
- 在不同类型的感染中探索BMI感染风险关联的变化.
主要方法:
- 一项大型队列研究涉及超过516,000名2型糖尿病患者和751,000名没有糖尿病的人,年龄,性别和种族相匹配.
- 分析了BMI类别 (≤19至>48 kg/m2),使用波松回归来估计感染的发病率比率 (IRR).
- 从2015-2019年期间的初级保健和住院记录中确定了感染,并对吸烟和并发症等混因素进行了调整.
主要成果:
- 与没有糖尿病的人相比,患有T2D的人在所有BMI水平上表现出更高的感染风险.
- 在T2D和非糖尿病组中观察到BMI和住院相关感染之间的U形关联.
- 初级保健感染主要与更高的BMI有关,而下呼吸道感染和败血症与低BMI和高BMI有关.
结论:
- 在T2D患者中,感染风险始终较高.
- 体重指数和感染风险之间的关系在患有和没有T2D的个体中似乎相似.
- 体重不足也是感染需要住院治疗的重要危险因素.
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