有效的微生物生产的纳米颗粒的耐受性类藻类 sp. 在HZ-9-3-3-3中使用
Omer Hassan Ali Hassan1, Ya-Ru Wei1, Zai-Ping Feng1
1School of Life Science and Engineering, Lanzhou University of Technology, No. 287 Langongping Road, Qilihe, Lanzhou, 730050, Gansu, People's Republic of China.
Current microbiology
|July 18, 2025
概括
使用Alcaligenes sp.进行纳米 (SeNPs) 的微生物合成. HZ-9-3-3提供了高的转换率. 这种菌株有效地产生具有显著抗氧化特性的SeNP,解决缺乏症.
科学领域:
- 生物技术是生物技术.
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
背景情况:
- (Se) 对于健康至关重要,但在全球范围内缺乏.
- 纳米 (SeNPs) 提供高生物可用性和低毒性.
- 微生物合成是SeNP生产的首选方法.
研究的目的:
- 隔离和识别用于SeNP生产的高耐受性微生物.
- 为高效的微生物生物转化优化条件.
- 描述生物合成的SeNP的抗氧化特性.
主要方法:
- 来自中国恩石的耐菌株的隔离,使用化梯度选.
- 鉴定产生SeNP的有力菌株 (Alcaligenes sp. 这就是为什么HZ-9-3-3).
- 优化生物转化参数 (注射器大小,pH,温度,化度) 使用单因素和中央复合设计 (CCD).
主要成果:
- 他们分离出了九种高耐受性菌株;Alcaligenes sp. HZ-9-3-3表现出耐受性高达0.231M的化.
- 在优化条件下 (12.7%的注射液,pH 7,28°C,0.0289 M Na2SeO3) 的转化率为69.7%.
- 生产的SeNP显示出中度的抗氧化活性 (DPPH的IC50为1.5 mg/mL,基为1.7 mg/mL) 和降低功率.
结论:
- 阿尔卡利格尼斯 (Alcaligenes) 种类 (sp. HZ-9-3-3是高效微生物SeNP生产的有希望的候选者.
- 优化的生物处理提高了转化效率.
- 生物合成的SeNP具有潜在的健康应用的显著抗氧化能力.
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