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病状况影响GCF MMP-9与血清维生素D相关:一个探索性回顾性横截面研究

Ayse Nur Doğan¹, Ayla Öztürk², Hatice Saraçoğlu³

¹School of Dentistry, Department of Restorative Dentistry, Erciyes University, Kayseri, Türkiye.

BMC oral health

|July 18, 2025

概括

矩阵金属蛋白酶-9 (MMP-9) 水平在牙中较高,可能会恶化牙腐烂. 维生素D缺乏可能会增加MMP-9,加速组织分解,增加对更深层感染的易感性.

科学领域:

口腔生物学和病理学
组织降解的生物化学.
营养对口腔健康的影响

背景情况:

矩阵金属蛋白酶-9 (MMP-9) 涉及到牙损期间的组织破坏.
维生素D缺乏可能会通过增加MMP-9表达来加剧牙.

研究的目的:

为了在健康,牙和恢复的牙中比较牙裂液 (GCF) 中的矩阵金属蛋白酶-9 (MMP-9) 水平.
为了研究血清维生素D水平与特定地点的GCF MMP-9度之间的关联.

主要方法:

一项涉及117名健康或牙炎状态的参与者的横截面研究.
从第一牙收集了GCF和血清维生素D样本.
使用ELISA测量MMP-9水平,通过ECLIA测量维生素D水平.

主要成果:

与健康和恢复的牙相比,牙的MMP-9水平显著更高.
在健康和恢复的牙之间没有发现MMP-9的显著差异.
维生素D缺乏症非常普遍 (90%),维生素D水平,病状况和牙周状况显著影响了MMP-9水平.

结论:

牙的GCF中MMP-9的升高表明牙的进展中发挥了作用.
维生素D缺乏可能会通过增强MMP-9产量而加剧.
研究结果表明,维生素D状况,MMP-9活性和空严重程度之间存在联系.

关键词:

牙腐烂是指牙的腐烂,也就是牙的腐烂.牙裂液是牙裂液中的一种液体.矩阵金属蛋白酶-9的作用维生素D 维生素D是一种维生素.

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