环境友好型电化学传感器用于在人体血中检测vildagliptin:绿色方法使用ZnO纳米粒子和石墨烯氧化物
Bassant Samy1, Mokhtar M Mabrouk2,3, Mohamed A Abdel Hamid2,3
1Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Shebin Elkom, Menoufia, Egypt.
BMC chemistry
|July 18, 2025
概括
使用氧化纳米粒子和氧化石墨烯改性电极的新型电压计传感器提供了一种快速,灵敏和选择性的方法,用于在制药样品和血中确定vildagliptin (VID).
科学领域:
- 电化学 电化学 电化学
- 纳米材料科学 科学 纳米材料科学
- 分析化学 分析化学
背景情况:
- 维尔达格利普丁 (VID) 是2型糖尿病管理中的一个关键的二二基酶-4抑制剂.
- 准确而敏感的VID量化对于治疗药物监测和质量控制至关重要.
- 开发高效的电化学传感器对于快速且具有成本效益的分析至关重要.
研究的目的:
- 开发一种敏感和选择性的电压测量方法,用于维达格利普丁 (VID) 测定.
- 描述一种用于增强电化学检测的新型改性电极.
- 在复杂的生物和制药矩阵中验证VID量化方法.
主要方法:
- 用氧化纳米粒子和氧化石墨烯 (ZnO-NPs/GOs/GCE) 修改的玻璃碳电极的制造.
- 使用循环电压测量和电化学阻抗光谱学进行电化学表征.
- 通过传输电子显微镜,FTIR和X射线光电谱学进行形态分析.
- 优化用于VID检测的实验参数.
主要成果:
- 该ZnO-NPs/GOs/GCE传感器表现出对VID氧化的增强电化学活性.
- 在15150μg/ml的范围内观察到VID确定的一种线性关系.
- 传感器实现了4.9微克/毫升的低检测极限 (LOD) 和15微克/毫升的量化极限 (LOQ).
- 该方法证明了出色的可重复性,可重复性和稳定性,在药物片和人体血样本中成功应用.
结论:
- 开发的ZnO-NPs/GOs/GCE修改电极提供了一个高度有效的平台,用于敏感和选择性的伏特美测定vildagliptin.
- 提出的分析方法是稳固的,可靠的,适合于质量控制和临床分析的实际应用.
- 绿色分析方法指数 (GAPI) 评估表明该方法的环保性.
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