三糖糖-葡萄糖指数和癌症风险:台湾的一项前性队列研究
Hsiao-Yun Yeh1,2,3, Mei-Hung Pan4, Chih-Jen Huang4
1Department of Medical Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 11217, Taipei, Taiwan.
Diabetology & metabolic syndrome
|July 18, 2025
概括
较高的甘油三-葡萄糖 (TyG) 指数水平,表明胰岛素耐药性,与增加消化,结直肠和尿路癌症的风险有关. 这种标志物可以帮助癌症风险分层和预防策略.
科学领域:
- 代谢健康 代谢健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 胰岛素抵抗 (IR) 是一种与不良健康结果相关的显著代谢异常,包括增加癌症风险.
- 甘油三糖 (TyG) 指数是IR的验证标志物,但其与大量人群癌症风险的关联需要进一步调查.
- 这项研究调查了台湾人口中TyG指数与癌症发病率之间的关系.
研究的目的:
- 评估甘油三糖指数 (TyG) 与患各种癌症的风险之间的关联.
- 确定TyG指数是否可以作为癌症风险的预测指标,特别是消化,结肠直肠和尿道癌症.
- 探索 TyG 指数在癌症风险分层和有针对性的预防策略中的潜在应用.
主要方法:
- 来自台湾生物库的150,592名参与者的分析,癌症发病率通过台湾癌症登记处 (2011-2022) 追踪.
- 在TyG指数的不同四分位数中对癌症风险的评估,平均随访时间为5.7年.
- 利用考克斯的比例危险模型来估计危险比率 (HRs) 和95%的置信区间 (CI),对相关的共变量进行调整.
主要成果:
- 提升的TyG指数水平与增加消化系统癌症 (aHR: 1.17),结直肠癌 (aHR: 1.25) 和尿路癌症 (aHR: 1.47) 的风险显著相关.
- 根据年龄和BMI的整体癌症风险,以及根据饮酒状况的尿路癌症风险,观察到显著的相互作用.
- 在一个子集中,较高的TyG指数四分位数与脂肪肝,心动脉斑块和持续的胰岛素抵抗相关.
结论:
- 较高的TyG指数水平,反映出更大的胰岛素抵抗,与消化,结直肠和尿路癌症的风险增加有关.
- 泰格指数显示,在持久性胰岛素耐药性个体中,在分层癌症风险方面具有潜在的有用性.
- 这些发现支持在制定有针对性的癌症预防策略时使用TyG指数.
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