纳灵宁对酸诱导的肝毒性在活体中的作用:一种剂量依赖性研究
Iftekhar Hassan1, Hossam Ebaid1, Badar Ul Islam2
1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Journal of applied toxicology : JAT
|July 19, 2025
概括
酸 (PB) 引起肝脏毒性,但宁素 (NIR) 在动物中有效减少这种损伤. NIR治疗改善了肝功能,并促进了亡而不是亡,显示了剂量依赖的保护作用,防止PB诱导的肝毒性.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 酸 (PB) 是一种食品添加剂和水处理副产品,因其剂量依赖性毒性和潜在致癌性而闻名.
- 长期暴露于PB可以导致严重的毒性侮辱和致癌.
- 纳灵宁 (NIR),一个突出的多,正在研究其对PB诱导毒性的潜在改善作用.
研究的目的:
- 为了评估纳灵 (NIR) 在减轻酸 (PB) 诱导的毒性在动物中的有效性.
- 评估与PB暴露和NIR干预相关的生化,分子和组织学变化.
- 为了确定NIR对PB诱导的肝损伤的剂量依赖性保护作用.
主要方法:
- 瑞士白色老鼠被分为五组:对照组,单独使用PB,单独使用NIR,以及两组与PB结合使用NIR治疗.
- 分别给各组使用PB (100 mg/kg) 和NIR (2或4 mg/kg).
- 收集肝脏和血液样本进行生物化学测试 (肝功能标志物,氧化还原状态,抗氧化酶),分子分析 (DNA完整性) 和组织病理学检查.
主要成果:
- PB的使用显著增加了肝功能标志物和诱导肝毒性,证据是被破坏的氧化还原平衡 (减少GSH,增加MDA) 和减少的抗氧化酶活性 (SOD,CAT).
- 单独的NIR显示了最小的毒性. 组合组在PB诱导的肝毒性标志物中显示出剂量依赖的改善.
- NIR干预降低了LDH活性和DNA损伤 (彗星形成),表明促进了亡而不是亡,同时显著恢复了肝脏组织学和抗氧化剂状况.
结论:
- 纳灵宁 (NIR) 在动物中以剂量依赖的方式有效地改善酸 (PB) 诱导的肝毒性.
- 通过恢复氧化还原平衡,增强抗氧化酶活性,促进亡,同时减少亡,NIR表现出保护作用.
- 尼尔有潜力用于含有PB的消费品或作为治疗剂,以减轻PB或类似化合物引起的肝毒性.
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