双重高剂量化疗和自身干细胞移植用于骨肉瘤与初始肺转移的肺癌
Hyun Jin Park1,2, Kyung Taek Hong1,2, Jung Yoon Choi1,2
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Pediatric blood & cancer
|July 19, 2025
概括
双重高剂量化疗与自身干细胞移植 (HDC/ASCT) 提供了转移性骨髓瘤的潜在治疗方法. 然而,需要修改治疗方案以减轻毒性,特别是严重的静脉闭塞性疾病.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 干细胞移植 干细胞移植
背景情况:
- 转移性骨肉瘤的预后不佳,尽管局部疾病治疗的进展.
- 在高风险骨髓瘤中,高剂量化疗与自身干细胞移植 (HDC/ASCT) 的疗效和最佳调节方案仍在研究中.
- 这项研究评估了新诊断的患有肺转移的骨髓瘤患者的双重HDC/ASCT.
研究的目的:
- 评估高剂量化疗与自身干细胞移植 (HDC/ASCT) 在患有肺转移的儿科骨髓瘤患者的双重高剂量化疗结果.
- 在这个患者队列中评估特定调节疗法的安全性和有效性 (梅尔法兰,埃托波西德,卡博普拉丁,其次是布苏尔法兰,梅尔法兰).
主要方法:
- 在诊断时,对11名骨髓瘤患者进行了肺转移的双重HDC/ASCT治疗的回顾性分析.
- 在第一个HDC中使用了梅尔法兰,埃托波西德和碳金,随后在第二个HDC中使用了布苏尔法兰和梅尔法兰.
- 随访时间的中位数为57.4个月.
主要成果:
- 5年无事件生存率为41.6%,整体生存率为68.2%.
- 在所有患者中都实现了移植;然而,36.4%的患者在第二次HDC/ASCT期间经历了严重的静脉封闭性疾病 (VOD).
- 与治疗相关的死亡发生在两名患者身上 (VOD和骨髓质疏松综合征),两人死于骨髓瘤进展.
结论:
- 双重HDC/ASCT可能是肺转移骨肉瘤患者的可行治疗选择,与历史数据相比,显示出有希望的生存率.
- 显著的毒性,特别是在第二次移植期间严重的VOD,需要修改调节方案.
- 需要进一步的研究来优化HDC/ASCT协议,以提高转移性骨髓瘤的安全性和疗效.
相关概念视频
01:21Stem Cell Therapy for Tissue Regeneration
4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:22Bone Marrow Sampling and Transplants
502
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
502
02:49Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K